Intraoperative fluid management is not predictive of AKI in major pancreatic surgery: a retrospective cohort study

Table 3 Postoperative and outcome variables

	Pancreatectomy No AKI (N = 180)	Pancreatectomy AKI (N = 20)	P value
KDIGO defined AKI stage (creatinine increase within 7 days post-surgery)
1 (≥ 1.5 times baseline or > 26.5 μmol/L in 48 h)	0	16
2 (≥ 2.0 times baseline)	0	1
3 (≥ 3.0 times baseline or > 353.7 μmol/L)	0	3
Acute renal failure requiring renal replacement therapy—n (%)^a	0 (0.0%)	2 (10.0%)	0.009
Infection (intrabdominal or sepsis)—n (%)^a	24 (13.3%)	8 (40.0%)	0.002
Clavien-Dindo Complication Score^a			0.004
1–2—n (%) (none, TPN, transfusion, or medical mgmt.)	141 (78.3%)	8 (47.1%)	< 0.01*
3–4—n (%) (procedural intervention or organ failure)	38 (21.1%)	9 (52.9%)	< 0.01*
5—n (%) (death)	1 (0.6%)	3 (15.0%)	< 0.001*
Clinically Relevant POPF—n^† (%)^a	17 (9.7%)	6 (33.3%)	< 0.001
Grade B	17 (9.7%)	4 (22.2%)	< 0.01*
Grade C	0 (0.0%)	2 (11.1%)	< 0.001*
Length of stay (days), median [25th percentile–75th percentile]	10 (7–15)	14 (12–20)	0.004
Disposition^a			< 0.001
Home—n (%)	143 (79.4%)	7 (35.0%)	< 0.001*
Skilled nursing facility—n (%)	36 (20.0%)	10 (50.0%)	< 0.01*
30-day mortality—n (%)	1 (0.6%)	3 (15.0%)	< 0.001*

Data are presented as the median [25th percentile–75th percentile], or percent
AKI acute kidney injury, KDIGO Kidney Disease Improving Global Outcomes, POPF postoperative pancreatic fistula, TPN total parenteral nutrition
^†POPF fistula percentages corrected for a total N of 193, representing a reduction from 200 to account for the 7 total pancreatectomy procedures
^aChi-square or Fisher’s exact test
^*Corrected for multiple comparisons

ISSN: 2731-3786