Table 3 Clinical characteristics at different time-points stratified by COVID-19 patients
Covid-19 NEGATIVE (n=7) | ||||||
|---|---|---|---|---|---|---|
Variables* | Baseline | 1 hour | 24 hours | 48 hours | 72 hours | p-value |
Arterial pH | 7.28 (7.24-7.32) | 7.37 (7.30-7.43) | 7.33 (7.29-7.39) | 7.35 (7.32-7.47) | 7.35 (7.31-7.42) | 0.09 |
PaCO2 mm Hg | 58 (54-72) | 51 (44-56) | 53 (47-64) | 53 (47-61) | 59 (53-61) | 0.43 |
PaO2 mm Hg | 119 (86-138) | 87 (86-96) | 106 (84-112) | 95 (82-98) | 81 (73-82) | 0.08 |
PaO2/ FiO2 ratio | 173 (140-225) | 124 (107-201) | 172 (116-235) | 177 (131-204) | 140 (130-202) | 0.41 |
Pplat cm H2O | 28 (22-30) | 25 (22-30) | 27 (24-32) | 27 (24-30) | 25 (24-29) | 0.16 |
VT ml/kg PBW | 6.7 (6.1-7.0) | 4.5 (4.0-5.7) | 5.2 (4.0-6.1) | 4.7 (4.0-6.1) | 4.7 (4.3-6.1) | 0.003 |
PEEP estr cm H2O | 11 (10-12) | 12 (12-14) | 12 (12-14) | 13 (11-15) | 13 (12-14) | 0.16 |
PEEP tot cm H2O | 12 (10-13) | 13 (12-14) | 13 (13-14) | 14 (12-16) | 14 (13-15) | 0.18 |
Driving pressure cm H2O | 15 (13-17) | 12 (10-16) | 14 (10-19) | 14 (10-17) | 11 (10-17) | 0.03 |
ComplianceRs cm H2O | 27 (20-40) | 23 (18-36) | 25 (13-43) | 21 (15-42) | 30 (14-43) | 0.37 |
Heparin IU/kg/h | - | 10 (10-11) | 11 (10-11) | 11 (10-15) | 11 (8-15) | 0.39 |
D-dimer µg/mL | 2.5 (1.1-3.8) | - | 1.3 (1.0-15.0) | 1.2 (1.0-17.9) | 1.8 (0.9-9.2) | 0.60 |
MAP, mm Hg | 70 (65-75) | 70 (68-75) | 68 (65-70) | 72 (72-80) | 80 (74-85) | 0.03 |
Norepinephrine μg/kg/min | 0.15 (0.06-0.50) | 0.20 (0.08-0.50) | 0.20 (0.08-0.60) | 0.40 (0.08-0.70) | 0.20 (0.06-0.30) | 0.12 |
VT ml | 440 (380-460) | 280 (250-320) | 300 (280-350) | 280 (280-420) | 300 (270-420) | 0.004 |
Vent/min L/min | 12.2 (11.0-16.1) | 9.0 (7.5-11.2) | 9.8 (6.9-12.3) | 9.8 (5.0-14.7) | 10.5 (5.6-14.7) | 0.06 |