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Table 2 Clinical characteristics at different time-points (n=14)

From: Lung (extracorporeal CO2 removal) and renal (continuous renal replacement therapy) support: the role of ultraprotective strategy in Covid 19 and non-Covid 19 ARDS. A case-control study

Variablesa

Baseline

1 hours

24 hours

48 hours

72 hours

p-value

Arterial pH

7.27 (7.22-7.31)

7.37 (7.31-7.39)

7.32 (7.26-7.37)

7.33 (7.31-7.36)

7.33 (7.29-7.36)

0.05

PaCO2 mm Hg

60.5 (56-77)

49 (44-58)

54.5 (47-61)

53.5 (46-61)

54 (47-61)

0.031

PaO2 mm Hg

96 (79-121)

86.5 (81-96)

88 (82-106)

92 (81-97)

82 (73-92)

0.41

PaO2/ FiO2 ratio

146.5 (113-173)

114.5 (102-130)

115 (103-172)

134 (107-177)

132.5 (107-153)

0.22

Pplat cm H2O

30 (27-35)

25.5 (24-28)

27.5 (26-32)

27.5 (26-28)

27 (25-28)

0.001

VT ml/kg PBW

6.7 (6.1-6.9)

5.1 (4.2-5.6)

5.2 (4.5-6.0)

5.0 (4.2-6.1)

5.2 (4.3-6.1)

<0.00012

PEEP estr cm H2O

11.5 (10-14)

14 (12-15)

13.5 (12-16)

14 (12-16)

14 (12-16)

0.03

PEEP tot cm H2O

12.5 (10-15)

14 (12-15)

14 (13-16)

14.5 (13-16)

14 (13-16)

0.01

Driving pressure cm H2O

17 (14-18)

11.5 (10-15)

13.5 (11-17)

12.5 (11-17)

11.5 (11-14)

0.00013

ComplianceRs cm H2O

26.5 (20-32)

25 (18-36)

25.5 (15-33)

29 (16-36)

30 (22-36)

0.13

Heparin IU/kg/h

-

11 (10-13)

11 (11-13)

11.5 (10-14)

11 (10-14)

0.47

aPTTr sec

1.5 (1.2-1.8)

-

1.8 (1.5-2.1)

1.8 (1.5-2.0)

1.9 (1.8-2.0)

0.02

D-dimer µg/mL

2.4 (1.1-3.2)

-

1.3 (1.2-2.3)

1.7 (1.2-2.6)

2.0 (1.7-2.7)

0.97

MAP, mm Hg

70.5 (65-75)

70 (68-75)

68.5 (65-70)

72 (70-80)

75.5 (70-80)

0.08

Norepinephrine μg/kg/min

0.20 (0.06-0.52)

0.25 (0.10-0.55)

0.25 (0.10-0.60)

0.45 (0.10-0.70)

0.29 (0.08-0.50)

0.15

VT ml

440 (380-450)

290 (280-360)

325 (280-350)

315 (280-380)

315 (280-400)

<0.00014

Vent/min L/min

15.1 (12.2-15.8)

9.8 (9-11.5)

10.7 (8.9-12.3)

10.8 (7.8-13.3)

11.1 (8.4-14.0)

0.00015

  1. aQuantitative variables are summarized as median and (IQR)
  2. Post-hoc comparison:
  3. 1Baseline VS. 1h p-value= 0.003
  4. 2Baseline VS. 1h p-value= 0.0001; baseline VS. 24h p-value= 0.0001; baseline VS. 48h p-value= 0.0004. baseline VS. 72h p-value= 0.0005
  5. 3Baseline VS. 1h p-value= 0.0004; baseline VS. 24h p-value= 0.001; baseline VS. 48h p-value= 0.003; baseline VS. 72h p-value= 0.0005
  6. 4Baseline VS. 1h p-value= 0.0001; baseline VS. 24h p-value= 0.0001; baseline VS. 48h p-value= 0.0005; baseline VS. 72h p-value= 0.0005
  7. 5Baseline VS. 1h p-value= 0.0009; baseline VS. 24h p-value= 0.003; baseline VS. 48h p-value= 0.004
  8. PaCO2 Partial pressure of arterial CO2, PaO2 Partial pressure of arterial O2, Pplat Plateau pressure, VT Tidal volume, PEEP Positive end-expiratory pressure (extrinsic or total); Driving pressure: driving pressure = Pplat minus PEEP; PaO2/FiO2 ratio: arterial-to-inspiratory oxygen fraction; MAP Mean arterial pressure
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Journal of Anesthesia, Analgesia and Critical Care

ISSN: 2731-3786

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