Fig. 7

Exemplary time courses for clinical effects of low-flow CO2 removal in patient with moderate ARDS due to pneumonia. A favorable response to ECCO2R treatment with sequential option for RR reduction. Figures represent three conditions: the first shows a standard treatment with ARDS net protocol application; the second shows an ultra-protective strategy (Ultra low Vt and high RR) supported by ECCO2R; the third illustrates a strategy coupling low Vt and low RR with ECCO2R support. In the two cases supported by extracorporeal support the values of PEEP were increased to reduce conditions of opening-closing avoiding hyperinflation. From top to bottom: tracings of flow, volume, airway, esophageal and transpulmonary pressure. Paw = airway pressure; Pes = esophageal pressure; PL = transpulmonary pressure